African Champions League 2016
Preliminaries / 2nd leg
2015 Champions: TP Mazembe (Congo DR)
2014 Champions: Entente Setif (Algeria)
| 23 Adokiye Amiesimaka Stadium, Port Harcourt | 28 Feb 2016 - 4 p.m. | |
 Enyimba |
2 : 0 | Vipers  |
| 24 Independence Stadium Bakau | 27 Feb 2016 - 4 p.m. | |
 Gamtel |
1 : 2 | Olympique Khouribga  |
| 25 National Stadium, Dar es Salaam | 27 Feb 2016 - 4 p.m. | |
 Young Africans |
2 : 0 | Cercle de Joachim  |
| 26 Lucas Masterpieces Moripe Stadium, Pretoria | 27 Feb 2016 - 3 p.m. | |
 mamelodi-sundowns |
2 : 0 | Chicken Inn  |
| 27 Rabemananjara Stadium, Mahajanga | 27 Feb 2016 - 4 p.m. | |
 CNaPS Sport |
1 : 0 | Gor Mahia  |
| 28 Stade Tata Raphaël, Kinshasa | 28 Feb 2016 - 3 p.m. | |
 AS Vita Club |
1 : 0 | Mafunzo  |
| 29 Estadio de Bata, Bata | 28 Feb 2016 - 4 p.m. | |
 Racing Micomseng |
0 : 4 | Recreativo do Libolo  |
| 30 Stade Alphonse Massemba-Débat, Brazzaville | 28 Feb 2016 - 3 p.m. | |
 Étoile du Congo |
3 : 0 | AS Mangasport  |
| 31 Stade du 28 Septembre, Conakry | 28 Feb 2016 - 3 p.m. | |
 Horoya |
4 : 0 | AS Douanes Dakar  |
| 33 Juba Stadium, Juba | 26 Feb 2016 - 3 p.m. | |
 Al Ghazal |
0 : 1 | ZESCO United  |
| 34 Moses Mabhida Stadium, Durban | 28 Feb 2016 - 4 p.m. | |
| Kaizer Chiefs |
- : - | Volcan Club  |
| 35 Stade Robert Champroux, Abidjan | 26 Feb 2016 - 4 p.m. | |
 AS Tanda |
0 : 0 | Club Africain  |
| 36 Stade Linité, Victoria | 27 Feb 2016 - 4 p.m. | |
 St Michel United |
1 : 1 | Saint George  |
| 37 Stade Régional Nyamirambo, Kigali | 27 Feb 2016 - 3 p.m. | |
 APR |
4 : 1 | Mbabane Swallows  |
| 38 Prince Louis Rwagasore Stadium, Bujumbura | 28 Mar 2016 - 4 p.m. | |
 Vital'O |
0 : 1 | Lioli  |
| 39 Stade Félix Houphouët-Boigny, Abidjan | 28 Feb 2016 - 3 p.m. | |
| ASEC Mimosas |
0 : 0 | AS CotonTchad  |
| 40 Stade de l'Unité Maghrébine, Béjaïa | 28 Feb 2016 - 4 p.m. | |
 Mouloudia Béjaïa |
3 : 1 | Ashanti Gold  |
| 41 Estádio Nacional 12 de Julho, São Tomé | 28 Feb 2016 - 3 p.m. | |
 Sporting Praia Cruz |
- : - | Warri Wolves |
| 42 Stade Olympique de Sousse, Sousse (Tunisia) | 26 Feb 2016 - 4 p.m. | |
 Al Ahli Tripoli |
0 : 0 | Onze Créateurs  |
| 43 Stade de la Réunification, Douala | 28 Feb 2016 - 4 p.m. | |
 Union Douala |
0 : 0 | Nimba United  |
| 44 Stade Général Seyni Kountché, Niamey | 28 Mar 2016 - 3 p.m. | |
 AS Douanes Niamey |
- : - | Wydad Casablanca |