African Champions League 2016
1st round / 2nd leg
2015 Champions: TP Mazembe
| 62 | 20 Mar 2016 - 4 p.m. | |
 Ferroviário da Beira |
1 : 1 | AS Vita Club  |
| 63 | 19 Mar 2016 - 4 p.m. | |
 AC Leopards |
1 : 1 | mamelodi-sundowns  |
| 64 | 19 Mar 2016 - 4 p.m. | |
 Al Merreikh |
1 : 0 | Warri Wolves  |
| 85 | 20 Mar 2016 - 4 p.m. | |
 Entente Setif |
4 : 2 | Étoile du Congo |
| 86 | 19 Mar 2016 - 4 p.m. | |
 CNaPS Sport |
2 : 1 | Wydad Casablanca  |
| 87 | 20 Mar 2016 - 4 p.m. | |
| TP Mazembe |
1 : 0 | Burundi  |
| 88 | 19 Mar 2016 - 4 p.m. | |
| Vital'O |
2 : 1 | Enyimba |
| 89 | 19 Mar 2016 - 4 p.m. | |
 Etoile du Sahel |
2 : 0 | Olympique Khouribga |
| 90 | 20 Mar 2016 - 4 p.m. | |
 Coton Sport |
1 : 0 | Stade Malien  |
| 91 | 20 Mar 2016 - 4 p.m. | |
 Horoya |
2 : 0 | ZESCO United  |
| 92 | 19 Mar 2016 - 4 p.m. | |
 Young Africans |
1 : 1 | APR  |
| 93 | 19 Mar 2016 - 4 p.m. | |
 Al Ahly SC |
2 : 0 | Recreativo do Libolo  |
| 94 | 20 Mar 2016 - 4 p.m. | |
 ASEC Mimosas |
0 : 0 | Kaizer Chiefs |
| 95 | 20 Mar 2016 - 4 p.m. | |
| Al Hilal |
2 : 1 | Al Ahli Tripoli  |
| 96 | 19 Mar 2016 - 4 p.m. | |
| Zamalek |
2 : 0 | Union Douala |
| 97 | 20 Mar 2016 - 4 p.m. | |
| Mouloudia Béjaïa |
2 : 0 | Club Africain |