Title-holders Entente Setif suffered a 2:1 home defeat against fellow Algerians USM Alger.
Senegal international striker Demba Ba is on the verge of joining Shanghai Shenhua
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Tunisia and Belgian coach George Leekens have parted ways.
Sudanese side Al Merreikh began the group phase with a 2:0 victory.
Etoile win as Ahly continue defence.
The three sides from Algeria, including reigning champions Entente Setif in GROUP B.
Tanzania has appointed former international Charles Boniface Mkwasa as interim coach.
Leeds United sign Ivory Coast defender Sol Bamba .
Burkina Faso striker Bertrand Traore is set to feature in Chelsea's first-team squad after being granted a work permit.
Portugal vs Ghana 3:2
FACTS
Goals Portugal
Cristiano Ronaldo (65'minutes pen), João Félix (78'minutes), Rafael Leão (80'minutes)
Assists
Bruno Fernandes (78'minutes, 80'minutes)
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Goals Ghana
A Ayew (73'minutes), Bukari (89'minutes)
Ghana
Portugal