Title-holders Entente Setif suffered a 2:1 home defeat against fellow Algerians USM Alger.
Senegal international striker Demba Ba is on the verge of joining Shanghai Shenhua
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Tunisia and Belgian coach George Leekens have parted ways.
Sudanese side Al Merreikh began the group phase with a 2:0 victory.
Etoile win as Ahly continue defence.
The three sides from Algeria, including reigning champions Entente Setif in GROUP B.
Tanzania has appointed former international Charles Boniface Mkwasa as interim coach.
Leeds United sign Ivory Coast defender Sol Bamba .
Burkina Faso striker Bertrand Traore is set to feature in Chelsea's first-team squad after being granted a work permit.
AFRICA CUP 2019
Quarter-Finals
Day 17
46th match
Nigeria vs South Africa 2:1
Goals Nigeria
Samuel Chukwueze 27', William Troost-Ekong 89'
Goal. South Africa
Bongani Zungu 71'
Video
Nigeria
South Africa